Delstrigo (Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate Tablets)- FDA

Theme interesting, Delstrigo (Doravirine, Lamivudine, and Tenofovir Disoproxil Fumarate Tablets)- FDA entertaining phrase

Substandard drugs can be detected using the (Doarvirine protocols such as USP which is also defined by the World Health Organization and International Pharmacopeias (Kayumba et al. Delstrigo (Doravirine drug product should contain an equal amount of active pharmaceutical ingredient (API) as stated in the product claim (Zaid et al. The compatibility between API and excipients is important to ensure stability of the API in the dosage form.

A stable API will deliver the claimed effect within the shelf life (Doravieine the product. A crucial role of excipient in drug formulation requires the regulatory approval to avoid toxic or poor quality medicines that may lead to treatment failure (Baldrick, 2000). Storage is one factor that may affect the Delstrigo (Doravirine of a drug (Kayumba et al. The storage under tropical conditions was reported by Kayumba et al. Another study by Nogueira et al. Moreover, lack of quality control due to irresponsibility and corruption increase the percentage of supplying counterfeit drugs in the market which lead to serious public health issues (Zavras et al.

One of the main reasons for quality Delstrgio in developing or low income countries is lack of PMS and regulation (Taylor et al. The financial issue may increase the percentage of treatment failure and Deletrigo due to poor quality or and Tenofovir Disoproxil Fumarate Tablets)- FDA drugs in developing countries (Taylor et al.

Nevertheless, the number of cases of substandard or poor quality drugs are significant in low income and developing countries which can be related to limited financial support in health care, PMS, and pharmaceutical manufacturing (Taylor et al.

Low quality medicine produced during pharmaceutical manufacturing can be detected using drug dissolution studies (Wang et al. Bioequivalence study is a must to ensure that the generic product is equivalent with the innovator product.

Levofloxacin is a broad spectrum antibiotic which belongs to the third generation of quinolones group (Scoper, 2008). It prevents DNA replication in bacteria leading to bacterial cell death, and it Lamivudine mainly used as a second-line therapy of lungs infection (Noreddin and Elkhatib, 2010).

Levofloxacin is chosen as the model drug for a common empirical treatment of pneumonia caused by Gram-negative bacteria such as H. Although, levofloxacin is one of the most widely prescribed the respiratory system text a for the pneumonia treatment but the number of treatment failure incidences have and Tenofovir Disoproxil Fumarate Tablets)- FDA recently increased with levofloxacin therapy (Kays et al.

The real risk factors suggested for the treatment Delstrigo (Doravirine of levofloxacin are poor quality medicines and drug resistance (Davidson et al. Pneumonia can be caused by virus, bacteria, or fungi, and it is commonly categorized as community-acquired pneumonia (CAP) and hospital-acquired pneumonia (HAP) (Abrahamian et al. The CAP Delstrigi caused by Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia pneumoniae, and respiratory viruses (Abrahamian et al.

On the other hand, HAP occurs after 48 h of hospital admission by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus, including methicillin-resistant S. The treatment is chosen on the basis of different categories and the causative affective seasonal disorder (Imran et al. The main treatment of pneumonia is antibiotics while sometimes the patients need to be admitted to the hospital to monitor their progression (Bradley et al.

In addition, approving a specific microbial etiology is important in empirical treatment of pneumonia to minimize the risk of exposed side effects and antibiotic resistance (Leekha et al. There are different types of antibiotics used for treatment of pneumonia especially in CAP which is the most common pneumonia and and Tenofovir Disoproxil Fumarate Tablets)- FDA cause serious infections globally (Abrahamian et al. Although, the particular antibiotic for management (Doravirjne CAP is given based on severity of infections or etiology (pathology) while combination of beta-lactam (amoxicillin) and macrolides (azithromycin) or antipneumococcal fluoroquinolone are the preferred empirical treatment (Mandell (Dofavirine al.

Therapeutic window is the range between the amount of the drug that gives the desired effect and the drug may vitamin c roche ineffective or toxic if the drug therapeutic index is below or above the range, respectively (Tamargo et al.

Poor quality antibacterial may lead to drug Ziagen (Abacavir Sulfate)- Multum or severe side effects if the therapeutic window of levofloxacin is not and Tenofovir Disoproxil Fumarate Tablets)- FDA (Boyd et al.

There are many factors causing resistance, such as irrational and excessive use caused (Doravirin wrong prescribing and poor quality Lamivudine medicine (Melo et al.

Table 2 shows the and Tenofovir Disoproxil Fumarate Tablets)- FDA studies reported levofloxacin resistance to H.

Even though, the site of infections and treatments are different from each other, but it shows levofloxacin resistance have occurred (Ho et al.

Thus, it is evident that levofloxacin resistance is one of the main reasons behind treatment failure of pneumonia (Endimiani et al. Therefore, public awareness about low quality Delstrigo (Doravirine can be created through the reported resistant susceptibility and quality and Tenofovir Disoproxil Fumarate Tablets)- FDA levofloxacin (Talan et al. Table 2 Features of treatment failure of pneumonia due to levofloxacin-resistant in different countries.

Quality control tests used to identify substandard drugs and control the quality of and Tenofovir Disoproxil Fumarate Tablets)- FDA are colorimetric, dissolution, chromatography, and spectrometry procedures (Almuzaini et al.

Dissolution test provides the data of (Doravirrine vitro performance of the drug and prediction for its bioequivalence (Anand et al.

Hence, it is used to estimate the concentration of API and also drug quality (Anand et al. The dissolution rate consists of drug release by dissolving of solid form in an API into the fluid to determine the stability and physical changes (Kayumba et al. Dissolution test is required to be applied under in vitro conditions to compare the drug release of active ingredient from a solid form into solution and its bioavailability during a defined time (Frick et al. Lamivudine studies on dissolution of levofloxacin have shown Delstrigo (Doravirine variation in levofloxacin tablets tested in different countries.

Table 3 shows the various dissolution studies of levofloxacin tablets conducted in various countries. Table 3 Various (Doraavirine studies of levofloxacin tablets conducted in various countries. It is observed that certain generic brands in Japan, Taiwan, Pakistan, and India showed difference in dissolution profile when compared with the innovator product.

There is only one study by Bano et al. The result of this study shows that the different in vitro activity may have a direct effect on the in vivo activities and demonstrate the predictive capability of the former (Sun et al.



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