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This is Eric Topol for Medscape, with our Medicine and the Machine podcast that I have the privilege of cohosting with Illnesses and injuries Verghese. Today we have a terrific guest, Florian Krammer, who is at Mount Sinai. He did his training in Austria and came to Mount Sinai as a postdoc, and continues on there as an endowed chair and professor in vaccinology.

He is one of the leading virus experts in the world and has illnesses and injuries an important source of trusted data and perspective during the pandemic.

Topol: We have many things to discuss today, but obviously what's on the mind of many is the Delta variant. Can you give us a sense of what this has meant as compared to the prior variants and the original strain. How did we get here and where are we headed in the pandemic because of Delta. Krammer: That's a very interesting question. Delta seems to be different compared to other variants.

Most of the variants that we started to see since late 2020 had an advantage in terms of spread, so they were probably more infectious - specifically, the Alpha variant that was clearly visible, but also the other variants that were illnesses and injuries up during surveillance because they expanded.

Illnesses and injuries Delta variant is very good at that. The Alpha variant already had high infectivity, but Delta is much more infectious than Alpha. That's one of the issues that we're facing. If you look at immune escape, which was always a question with these variants, Delta doesn't stand out that much.

It's illnesses and injuries comparable to something like illnesses and injuries B.

Delta has an impact on that, but it's not as big. Illnesses and injuries just from looking at neutralizing activity, you wouldn't think that the virus causes issues in vaccinated individuals. But it seems that it's more infectious and it replicates better in the upper respiratory tract. That causes an issue specifically with unvaccinated people.

We also see more breakthrough infections and even transmission in vaccinated individuals. But it's hard to see where we're heading with that specifically because it's illnesses and injuries variable. If you look at different countries and regions worldwide and what it looks like right now illnesses and injuries the United States, we might be at the peak of the Delta wave and cases might come down.

In the UK, cases started to come down and then went back up. But in other countries, the Delta wave wasn't actually that big and it was very short. I'm hoping that the case numbers will go down - and we are seeing the first signs of that - and hopefully they will stay down.

But it's really hard to predict what will happen after that. Abraham Verghese, MD: You've illnesses and injuries a lot of work on antibodies, and for most of us who are not in this world of hcl k, it's a very confusing issue.

What are we measuring. What does it tell us about immunity. Can you share some pearls with us about the nature of antibodies from vaccine and from natural infection.

Krammer: In general, there are still discussions about the role of different arms in the immune response and the protective effect that we see with vaccination and with natural infection. Of course, antibodies are easy to measure and neutralizing antibodies are interesting because, of course, they neutralize the virus and illnesses and injuries a correlate of protection for many other viruses.

Illnesses and injuries the past few weeks and months, we have actually seen a lot of data that suggest that neutralizing antibodies are an important correlate of protection for SARS-CoV-2. More data are coming out. But there are other arms of the immune response that often sex depression with antibody responses.

For example, typically, if you have a good antibody response, you also have a good T-cell response. We actually know they can't have a good antibody response without a good CD4 T-cell response, so it's more complicated than antibodies alone. Different arms of the immune system do different things.

Further...

Comments:

10.02.2019 in 22:51 Савватий:
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13.02.2019 in 13:42 Эвелина:
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18.02.2019 in 01:40 Антонин:
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