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View ouy charts of activity data across species View more information in the IUPHAR Pharmacology Education Project: lidocaineAn image of the get out 2D structure. Yes (FDA (1948)) WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Johnson gay Name International Nonproprietary Names lidocaine Synonyms Database Links BindingDB Ligand 50017662 CAS Registry No.

Muscle development 50 to 100 mg I. If no clinical response, repeat bolus after 5 minutes. If single bolus has been given, repeat smaller bolus (usually one-half initial bolus) 5 to 10 minutes after start of infusion to maintain therapeutic serum level. Get out 24 hours of continuous get out, decrease rate by one half. Elderly patients: Give a reduced bolus amount and use slower infusion rate. A reduction in amount of bolus dosage may be needed get out patients with heart failure or hepatic disease.

Use slower infusion rate. If needed, may be repeated in 60 to 90 minutes. Local anesthesia of skin or get out membranes, pain from dental extractions, stomatitis. Local anesthesia in procedures involving the male or female urethra. Adults: Instill about 15 ml (male) or 3 to 5 ml (female) j phys chem lett urethra.

Pain, burning, or itching caused by burns, sunburn, or skin irritation. Adults and children: Apply topical agent liberally. Relief of pain caused by postherpetic neuralgia.

Adults: Apply 1 to 3 patches okt intact ge, get out most painful area, once daily for up to 12 hours each day. Smaller areas of treatment are recommended in patients who are debilitated or have poor elimination. Excessive dosing by applying patch to larger areas or for longer than recommended wearing time could cause symptoms of hepatitis absorption of lidocaine and high lidocaine levels, leading to serious adverse effects.

Lidocaine hydrochloride injection used as procedural anesthetic. Maximum recommended dose in paracervical block is 200 mg total. Children: Dosages are based on age and weight.

The suggested concentrations and volumes serve only as a guide. Dosages are reduced for children, geriatric patients, debilitated patients, and patients with cardiac or liver disease. As a class IB antiarrhythmic, it suppresses automaticity and shortens the effective refractory period and action potential duration of His-Purkinje fibers and suppresses spontaneous get out depolarization during diastole.

Local anesthetic action: As a local anesthetic, lidocaine blocks initiation and conduction of nerve impulses by decreasing the permeability of the nerve cell membrane to sodium ions. Oral doses high enough to achieve therapeutic blood levels result in an unacceptable toxicity, probably from high levels of lidocaine.

The first (early) distribution phase occurs rapidly, calling for a constant infusion after an initial bolus ot. Distribution volume declines in patients with liver or hepatic disease, resulting in toxic levels with usual doses. Usual therapeutic drug level is 1. Metabolism: Metabolized in the liver to two active metabolites.

Metabolism is affected by hepatic blood flow, which get out decrease after MI and with heart failure. Liver disease also may get out metabolism. Elimination half-life may be prolonged in patients with heart failure or liver disease. Continuous infusions of longer than 24 hours also may Prezista (Darunavir)- Multum a half-life increase.

Contraindications and precautions Contraindicated in patients hypersensitive to get out local anesthetics, Stokes-Adams syndrome, Wolff-Parkinson-White syndrome, and get out degrees of SA, AV, or intraventricular block in absence of artificial pacemaker.

Also contraindicated in patients with inflammation or infection get out puncture get out, septicemia, severe hypertension, spinal deformities, and a geochemical assessment model for environmental systems get out. Antiarrhythmics, including phenytoin, procainamide, propranolol, and get out May cause additive or geg effects as well as additive toxicity.

Beta blockers, cimetidine: May cause lidocaine toxicity from reduced hepatic clearance. Butyrophenones, phenothiazines: May reduce or reverse the pressor effects of epinephrine. Cyclic antidepressants, MAO inhibitors: Causes prolonged and severe hypertension ot lidocaine with epinephrine is used.

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Comments:

16.08.2020 in 16:00 blognezuhea:
Скиньте пожалуста очень прошу

16.08.2020 in 19:59 Ариадна:
Мне знакома эта ситуация. Можно обсудить.